C9^em1Sjlg
Endonuclease-mediated Allele Detail

Summary

• Symbol: C9^em1Sjlg
• Name: complement component 9; endonuclease-mediated mutation 1, Shujuan Liang
• MGI ID: MGI:6514830
• Gene: C9 Location: Chr15:6474808-6528232 bp, + strand Genetic Position: Chr15, 2.79 cM, cytoband A1
• Alliance: C9^em1Sjlg page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: TALEN-targeting of exon 1 deleted 34 bp. Western blot analysis confirmed the absence of protein expression in the serum and liver. (J:301607)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any C9 Mutation: 44 strains or lines available

References

• Original: J:301607 Fu X, et al., Target deletion of complement component 9 attenuates antibody-mediated hemolysis and lipopolysaccharide (LPS)-induced acute shock in mice. Sci Rep. 2016 Jul 22;6:30239
• All: 1 reference(s)