Fbxl4^tm1.1Lrsn
Targeted Allele Detail

Summary

• Symbol: Fbxl4^tm1.1Lrsn
• Name: F-box and leucine-rich repeat protein 4; targeted mutation 1.1, Nils-Goran Larsson
• MGI ID: MGI:6514031
• Synonyms: Fbxl4^loxP
• Gene: Fbxl4 Location: Chr4:22357543-22434091 bp, + strand Genetic Position: Chr4, 9.69 cM
• Alliance: Fbxl4^tm1.1Lrsn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303084
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT site flanked puromycin resistance gene cassette were inserted into intron 3 and a second loxP site into intron 4. The puro cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 4 floxed. (J:303084)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fbxl4 Mutation: 33 strains or lines available

References

• Original: J:303084 Alsina D, et al., FBXL4 deficiency increases mitochondrial removal by autophagy. EMBO Mol Med. 2020 Jul 7;12(7):e11659
• All: 1 reference(s)