Trim35^em1Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim35^em1Smoc
• Name: tripartite motif-containing 35; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
• MGI ID: MGI:6512427
• Synonyms: Trim35^-
• Gene: Trim35 Location: Chr14:66534480-66548873 bp, + strand Genetic Position: Chr14, 34.44 cM, cytoband D1
• Alliance: Trim35^em1Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2-4 of the gene were deleted using CRISPR/Cas9 technology. Immunoblot analysis of lung extracts confirmed the absence of protein in homozygous mutant mice. (J:303214)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim35 Mutation: 32 strains or lines available

References

• Original: J:303214 Sun N, et al., TRIM35 mediates protection against influenza infection by activating TRAF3 and degrading viral PB2. Protein Cell. 2020 Dec;11(12):894-914
• All: 1 reference(s)