Erc1^tm1.1Toh
Targeted Allele Detail

Summary

• Symbol: Erc1^tm1.1Toh
• Name: ELKS/RAB6-interacting/CAST family member 1; targeted mutation 1.1, Toshisa Ohtsuka
• MGI ID: MGI:6512418
• Synonyms: Elks^fl
• Gene: Erc1 Location: Chr6:119547757-119825128 bp, - strand Genetic Position: Chr6, 56.86 cM, cytoband F1
• Alliance: Erc1^tm1.1Toh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:269480
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP sequence and phosphoglycerate kinase 1 (Pgk-1) promoter-driven neomycin phosphotransferase (neo) gene flanked by two Flp recognition target (frt) sites was inserted into 493-bp upstream of exon 11, and the second loxP sequence was inserted 243-bp downstream of exon 11. The neo gene was removed in vivo via Flp-mediated recombination in the germline. (J:269480)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erc1 Mutation: 61 strains or lines available

References

• Original: J:269480 Dong W, et al., CAST/ELKS Proteins Control Voltage-Gated Ca(2+) Channel Density and Synaptic Release Probability at a Mammalian Central Synapse. Cell Rep. 2018 Jul 10;24(2):284-293.e6
• All: 5 reference(s)