Sema7a^em3Smoc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sema7a^em3Smoc
• Name: sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
• MGI ID: MGI:6511749
• Synonyms: Sema7a (R145W)
• Gene: Sema7a Location: Chr9:57847395-57870148 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband A3.3-B
• Alliance: Sema7a^em3Smoc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Not Specified)
• Mutation: Single point mutation
• Mutation details: CRISPR-targeting engineered the amino acid substitution of arginine to tryptophan at position 145 (R145W). (J:330840)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sema7a Mutation: 36 strains or lines available

References

• Original: J:330840 Zhao N, et al., SEMA7AR148W mutation promotes lipid accumulation and NAFLD progression via increased localization on the hepatocyte surface. JCI Insight. 2022 Aug 8;7(15):e154113
• All: 3 reference(s)