Aqp1^tm1Tsna
Targeted Allele Detail

Summary

• Symbol: Aqp1^tm1Tsna
• Name: aquaporin 1; targeted mutation 1, Tsutomu Nakada
• MGI ID: MGI:6510235
• Synonyms: AQP-1^flox
• Gene: Aqp1 Location: Chr6:55313417-55325540 bp, + strand Genetic Position: Chr6, 27.38 cM
• Alliance: Aqp1^tm1Tsna page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302794
• Parent Cell Line: RENKA (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The 34-bp loxP sequence with 26-bp linker sequence was inserted into the site 210 bp upstream of exon 2. A 1.8 kb DNA fragment, which carried the 34 bp loxP sequence and Pgk-1 promoter-driven neomycin phosphotransferase gene (neo) flanked by two Flp recognition target (frt) sites was then inserted into the site 190 bp downstream of exon 3. (J:302794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Aqp1 Mutation: 27 strains or lines available

References

• Original: J:302794 Igarashi H, et al., Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice. Neuroreport. 2014 Jan 8;25(1):39-43
• All: 1 reference(s)