Htr6^tm1Ics
Targeted Allele Detail

Summary

• Symbol: Htr6^tm1Ics
• Name: 5-hydroxytryptamine (serotonin) receptor 6; targeted mutation 1, Mouse Clinical Institute
• MGI ID: MGI:6509114
• Synonyms: 5-HT6-GFP KI
• Gene: Htr6 Location: Chr4:138788419-138802881 bp, - strand Genetic Position: Chr4, 70.57 cM
• Alliance: Htr6^tm1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:238800
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: An EGFP cDNA was introduced in frame at the end of exon 4 of the coding region of the gene, removing the receptors stop codon and generating a C-terminally tagged receptor. The GFP-tagged receptor showed membrane expression and functionality similar to the WT receptor. (J:238800)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htr6 Mutation: 26 strains or lines available

References

• Original: J:238800 Deraredj Nadim W, et al., Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity. Proc Natl Acad Sci U S A. 2016 Oct 25;113(43):12310-12315
• All: 6 reference(s)