Rb1cc1^tm2.1Guan
Targeted Allele Detail

Summary

• Symbol: Rb1cc1^tm2.1Guan
• Name: RB1-inducible coiled-coil 1; targeted mutation 2.1, Jun-Lin Guan
• MGI ID: MGI:6508981
• Synonyms: FIP200-4A, FIP200^KI
• Gene: Rb1cc1 Location: Chr1:6284858-6346599 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2
• Alliance: Rb1cc1^tm2.1Guan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232491
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: This allele expresses a protein with a 582585 LQFL-to-AAAA substitution encoded by nucleotide changes in the exon 13 coding region. An frt-flanked neomycin cassette was removed from the allele via FLP1-mediated recombination in the germline. (J:232491)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rb1cc1 Mutation: 85 strains or lines available

References

• Original: J:232491 Chen S, et al., Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model. Genes Dev. 2016 Apr 1;30(7):856-69
• All: 3 reference(s)