Trim2^em3Srr
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trim2^em3Srr
• Name: tripartite motif-containing 2; endonuclease-mediated mutation 3, Susan R Ross
• MGI ID: MGI:6508123
• Synonyms: line C, Trim2^C
• Gene: Trim2 Location: Chr3:84067746-84214184 bp, - strand Genetic Position: Chr3, 37.48 cM, cytoband F1
• Alliance: Trim2^em3Srr page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 genome editing technology was used to generate a small deletion, which removed sequence encoding 30 amino acids, including the C-terminal portion of the RING domain, and then retains the rest of the encoded protein. (J:273377)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim2 Mutation: 41 strains or lines available

References

• Original: J:273377 Sarute N, et al., TRIM2, a novel member of the antiviral family, limits New World arenavirus entry. PLoS Biol. 2019 Feb;17(2):e3000137
• All: 2 reference(s)