Scn1b^tm2.2Isom
Targeted Allele Detail

Summary

• Symbol: Scn1b^tm2.2Isom
• Name: sodium channel, voltage-gated, type I, beta; targeted mutation 2.2, Lori L Isom
• MGI ID: MGI:6508110
• Synonyms: Scn1b^flox
• Gene: Scn1b Location: Chr7:30815949-30826428 bp, - strand Genetic Position: Chr7, 19.3 cM
• Alliance: Scn1b^tm2.2Isom page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302071
• Parent Cell Line: Pat5 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted 190 bp upstream and 220 bp downstream of exon 2. A FRT-flanked neomycin cassette was that was inserted further downstream of exon 2 was subsequently removed via FLP1-mediated recombination in the germline. (J:128713)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn1b Mutation: 8 strains or lines available

References

• Original: J:302071 Lin X, et al., Scn1b deletion leads to increased tetrodotoxin-sensitive sodium current, altered intracellular calcium homeostasis and arrhythmias in murine hearts. J Physiol. 2015 Mar 15;593(6):1389-407
• All: 5 reference(s)