Nrg2^tm1.1Bnno
Targeted Allele Detail

Summary

• Symbol: Nrg2^tm1.1Bnno
• Name: neuregulin 2; targeted mutation 1.1, Andres Buonanno
• MGI ID: MGI:6508087
• Synonyms: NRG2 KO
• Gene: Nrg2 Location: Chr18:36150705-36330433 bp, - strand Genetic Position: Chr18, 19.38 cM
• Alliance: Nrg2^tm1.1Bnno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301708
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: LoxP sites were inserted into the intron upstream of exon 5 (encoding the EGF domain) and downstream of exon 8 encoding the transmembrane domain (TM). Exons 5-8 were deleted via Cre-mediated recombination in the germline. (J:301708)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg2 Mutation: 33 strains or lines available

References

• Original: J:301708 Yan L, et al., Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. Mol Psychiatry. 2018 May;23(5):1233-1243
• All: 1 reference(s)