Nrg2tm1.1Bnno
Targeted Allele Detail
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Symbol: |
Nrg2tm1.1Bnno |
Name: |
neuregulin 2; targeted mutation 1.1, Andres Buonanno |
MGI ID: |
MGI:6508087 |
Synonyms: |
NRG2 KO |
Gene: |
Nrg2 Location: Chr18:36150705-36330433 bp, - strand Genetic Position: Chr18, 19.38 cM
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Alliance: |
Nrg2tm1.1Bnno page
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Germline Transmission: |
Earliest citation of germline transmission:
J:301708
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: LoxP sites were inserted into the intron upstream of exon 5 (encoding the EGF domain) and downstream of exon 8 encoding the transmembrane domain (TM). Exons 5-8 were deleted via Cre-mediated recombination in the germline.
(J:301708)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Nrg2 Mutation: |
32 strains or lines available
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Original: |
J:301708 Yan L, et al., Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders. Mol Psychiatry. 2018 May;23(5):1233-1243 |
All: |
1 reference(s) |
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