Pask^tm1Gsxil
Targeted Allele Detail

Summary

• Symbol: Pask^tm1Gsxil
• Name: PAS domain containing serine/threonine kinase; targeted mutation 1, Gabriela da Silva Xavier
• MGI ID: MGI:6508060
• Synonyms: Pask^fl, Pask^tm1Rttr
• Gene: Pask Location: Chr1:93237165-93271237 bp, - strand Genetic Position: Chr1, 47.24 cM, cytoband D
• Alliance: Pask^tm1Gsxil page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:236420
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6JOlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A single loxP site was inserted 3' to exon 15 and a floxed neomycin selectable marker cassette was inserted 204 bp downstream of exon 11 and 200 bp upstream of exon 12. Exons 11 - 15 encode the Ser/Thr kinase domain. (J:236420)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pask Mutation: 56 strains or lines available

Notes

ES cell= AZX1 (C57BL/6JOlaHsd)

References

• Original: J:236420 Semplici F, et al., Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. Diabetologia. 2016 Sep;59(9):1938-47
• All: 1 reference(s)