Chat^tm1.1Mlt
Targeted Allele Detail

Summary

• Symbol: Chat^tm1.1Mlt
• Name: choline O-acetyltransferase; targeted mutation 1.1, Jacques Mallet
• MGI ID: MGI:6508040
• Synonyms: ChAT^-
• Gene: Chat Location: Chr14:32130160-32187866 bp, - strand Genetic Position: Chr14, 19.4 cM
• Alliance: Chat^tm1.1Mlt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260504
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP-flanked neomycin cassette was inserted upstream of exon 8 and a third loxP sequence in intron 8. Cre mediated recombinase removed the neo cassette and exon8, resulting in a frame-shift mutation and a truncated protein. (J:212048)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chat Mutation: 63 strains or lines available

References

• Original: J:260504 Lecomte MJ, et al., Acetylcholine Modulates the Hormones of the Growth Hormone/Insulinlike Growth Factor-1 Axis During Development in Mice. Endocrinology. 2018 Apr 1;159(4):1844-1859
• All: 2 reference(s)