Gabra2^tm2Stmo
Targeted Allele Detail

Summary

• Symbol: Gabra2^tm2Stmo
• Name: gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 2, Stephen J Moss
• MGI ID: MGI:6508036
• Synonyms: Gabra2-1
• Gene: Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
• Alliance: Gabra2^tm2Stmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: The codon sequences from 358375 from the Gabra1 gene were inserted into exon 10 of the Gabra2 gene, replacing the codons in Gabra2 corresponding within the large intracellular loop of the encoded protein. (J:266404)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra2 Mutation: 37 strains or lines available

References

• Original: J:266404 Hines RM, et al., Developmental seizures and mortality result from reducing GABAA receptor alpha2-subunit interaction with collybistin. Nat Commun. 2018 Aug 7;9(1):3130
• All: 1 reference(s)