Sall1^tm2.1Mrau
Targeted Allele Detail

Summary

• Symbol: Sall1^tm2.1Mrau
• Name: spalt like transcription factor 1; targeted mutation 2.1, Michael Rauchman
• MGI ID: MGI:6508034
• Synonyms: deltaSRM
• Gene: Sall1 Location: Chr8:89753867-89770790 bp, - strand Genetic Position: Chr8, 43.51 cM, cytoband D
• Alliance: Sall1^tm2.1Mrau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:243561
• Parent Cell Line: SCC10 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutation: Nucleotide substitutions
• Mutation details: Four DNA base pair mutations in exon 1 were inserted to alter codons to encode a triple amino acid mutation [R3R4(G)K5(A)]. An frt-flanked neomycin selection cassette was removed via FLP1-mediated recombination. (J:243561)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sall1 Mutation: 77 strains or lines available

References

• Original: J:243561 Basta JM, et al., A Sall1-NuRD interaction regulates multipotent nephron progenitors and is required for loop of Henle formation. Development. 2017 Sep 01;144(17):3080-3094
• All: 1 reference(s)