Agtr1a^tm1.1Ttok
Targeted Allele Detail

Summary

• Symbol: Agtr1a^tm1.1Ttok
• Name: angiotensin II receptor, type 1a; targeted mutation 1.1, Takeshi Tokudome
• MGI ID: MGI:6507967
• Synonyms: Agtr1a^fl
• Gene: Agtr1a Location: Chr13:30520424-30566850 bp, + strand Genetic Position: Chr13, 13.19 cM
• Alliance: Agtr1a^tm1.1Ttok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302255
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site and frt-flanked neomycin-selection cassette were inserted upstream of exon 3 and second loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the neomycin selection cassette, leaving exon 3 floxed. (J:302255)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr1a Mutation: 38 strains or lines available

References

• Original: J:302255 Otani K, et al., Deficiency of Cardiac Natriuretic Peptide Signaling Promotes Peripartum Cardiomyopathy-Like Remodeling in the Mouse Heart. Circulation. 2020 Feb 18;141(7):571-588
• All: 1 reference(s)