Foxp3^tm1.1Mono
Targeted Allele Detail

Summary

• Symbol: Foxp3^tm1.1Mono
• Name: forkhead box P3; targeted mutation 1.1, Masahiro Ono
• MGI ID: MGI:6507445
• Synonyms: Foxp3-Tocky
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^tm1.1Mono page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:264610
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Using BAC RP23-330D17, the first coding exon was replaced with a cassette containing the Fast Fluorescent Timer gene, poly(A) signal sequences and a loxP site flanked neomycin resistance gene cassette. The neo cassette was removed through subsequent cre-mediated recombination. The FT gene is a mutated form of mCherry (M18V E34K K69R L84W S149T A224S). (J:264610)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 57 strains or lines available

References

• Original: J:264610 Bending D, et al., A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo. J Cell Biol. 2018 Aug 6;217(8):2931-2950
• All: 3 reference(s)