Disc1^tm1.1Hsng
Targeted Allele Detail

Summary

• Symbol: Disc1^tm1.1Hsng
• Name: disrupted in schizophrenia 1; targeted mutation 1.1, Hongjun Song
• MGI ID: MGI:6507434
• Gene: Disc1 Location: Chr8:125780934-125988597 bp, + strand Genetic Position: Chr8, 73.26 cM
• Alliance: Disc1^tm1.1Hsng page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:304928
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Intragenic deletion
• Mutation details: The targeting construct is designed to delete 4 base pairs (TCTT) in exon 12 of the gene. This deletion is analogous to a deletion found in patients with neuropsychiatric disorders such as schizophrenia. A loxP flanked neomycin (neo) resistance cassette was inserted downstream of the deletion. Germ line, cre mediated recombination removed the neo cassette. (J:304928)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Disc1 Mutation: 68 strains or lines available

References

• Original: J:304928 Kim NS, et al., Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation. Nat Commun. 2021 Mar 3;12(1):1398
• All: 2 reference(s)