Slc9a3^{tm4.1(Hbegf)Niba}
Targeted Allele Detail

Summary

• Symbol: Slc9a3^{tm4.1(Hbegf)Niba}
• Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3; targeted mutation 4.1, Nick Barker
• MGI ID: MGI:6507188
• Synonyms: Slc9a3-2A-DTR
• Gene: Slc9a3 Location: Chr13:74269576-74317561 bp, + strand Genetic Position: Chr13, 40.15 cM
• Alliance: Slc9a3^{tm4.1(Hbegf)Niba} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:292580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Slc9a3^{tm4.1(Hbegf)Niba} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: Sequence for the 2A self-cleaving peptide, a diphtheria toxin receptor (HBEGF/DTR) cDNA and a loxP site flanked neomycin resistance gene cassette were inserted immediately before the stop codon. The neo cassette was removed through subsequent cre-mediated recombination. This allele expresses the endogenous peptide and the inserted DTR peptide. (J:292580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc9a3 Mutation: 45 strains or lines available

References

• Original: J:292580 Tan SH, et al., AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020 Feb;578(7795):437-443
• All: 1 reference(s)