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Phf6tm1.2Avo
Targeted Allele Detail
Nomenclature
Symbol: Phf6tm1.2Avo
Name: PHD finger protein 6; targeted mutation 1.2, Anne K Voss
MGI ID: MGI:6507035
Gene: Phf6  Location: ChrX:52001143-52045820 bp, + strand  Genetic Position: ChrX, 29.28 cM, cytoband A4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:276228
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of exon 4 and an FRT-flanked neomycin selection cassette followed by a second loxP site were inserted downstream of exon 5. The neomycin cassette was removed via Flp-mediated recombination. Exons 4 and 5 were removed via cre-mediated recombination. (J:276228)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Phf6 Mutation:  10 strains or lines available
References
Original:  J:276228 McRae HM, et al., PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia. Blood. 2019 Apr 18;133(16):1729-1741
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory