Havcr1^tm2.1Kuch
Targeted Allele Detail

Summary

• Symbol: Havcr1^tm2.1Kuch
• Name: hepatitis A virus cellular receptor 1; targeted mutation 2.1, Vijay Kuchroo
• MGI ID: MGI:6506848
• Synonyms: Tim-1^fl
• Gene: Havcr1 Location: Chr11:46630644-46670405 bp, + strand Genetic Position: Chr11, 28.08 cM
• Alliance: Havcr1^tm2.1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301616
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 2-3 floxed. (J:301616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Havcr1 Mutation: 29 strains or lines available

References

• Original: J:301616 Xiao S, et al., Checkpoint Receptor TIGIT Expressed on Tim-1(+) B Cells Regulates Tissue Inflammation. Cell Rep. 2020 Jul 14;32(2):107892
• All: 1 reference(s)