Tigit^tm1.1Kuch
Targeted Allele Detail

Summary

• Symbol: Tigit^tm1.1Kuch
• Name: T cell immunoreceptor with Ig and ITIM domains; targeted mutation 1.1, Vijay Kuchroo
• MGI ID: MGI:6506843
• Synonyms: Tigit^fl
• Gene: Tigit Location: Chr16:43469230-43484509 bp, - strand Genetic Position: Chr16, 28.44 cM
• Alliance: Tigit^tm1.1Kuch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:301616
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 1. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 1 floxed. (J:301616)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tigit Mutation: 31 strains or lines available

References

• Original: J:301616 Xiao S, et al., Checkpoint Receptor TIGIT Expressed on Tim-1(+) B Cells Regulates Tissue Inflammation. Cell Rep. 2020 Jul 14;32(2):107892
• All: 1 reference(s)