Psen1^tm2.1Bdes
Targeted Allele Detail

Summary

• Symbol: Psen1^tm2.1Bdes
• Name: presenilin 1; targeted mutation 2.1, Bart de Strooper
• MGI ID: MGI:6506066
• Synonyms: Psen1^f
• Gene: Psen1 Location: Chr12:83734926-83781869 bp, + strand Genetic Position: Chr12, 38.84 cM
• Alliance: Psen1^tm2.1Bdes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:275647
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced in intron 1 and the second together with a Frt-flanked hygromycin B selection marker cassette was inserted into intron 2. The selection cassette was deleted via FLP-mediated recombination in the germline. (J:275647)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Psen1 Mutation: 61 strains or lines available

References

• Original: J:275647 Habets RA, et al., Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition. Sci Transl Med. 2019 May 29;11(494)
• All: 1 reference(s)