Chd8^tm2Kei
Targeted Allele Detail

Summary

• Symbol: Chd8^tm2Kei
• Name: chromodomain helicase DNA binding protein 8; targeted mutation 2, Keiichi I Nakayama
• MGI ID: MGI:6505573
• Synonyms: Chd8L^F
• Gene: Chd8 Location: Chr14:52435608-52495237 bp, - strand Genetic Position: Chr14, 26.84 cM
• Alliance: Chd8^tm2Kei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235128
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• A pair of loxP sites and a loxP-flanked neo gene cassette flank exons 11 to 13. (J:235128)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chd8 Mutation: 107 strains or lines available

References

• Original: J:235128 Katayama Y, et al., CHD8 haploinsufficiency results in autistic-like phenotypes in mice. Nature. 2016 Sep 29;537(7622):675-679
• All: 7 reference(s)