Oprk1^tm3.1Llch
Targeted Allele Detail

Summary

• Symbol: Oprk1^tm3.1Llch
• Name: opioid receptor, kappa 1; targeted mutation 3.1, Lee-Yuan Liu-Chen
• MGI ID: MGI:6505571
• Synonyms: K4A, Oprk1^{tm3.1(K4A)Llch}
• Gene: Oprk1 Location: Chr1:5658689-5676354 bp, + strand Genetic Position: Chr1, 1.89 cM, cytoband A2-A3
• Alliance: Oprk1^tm3.1Llch page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:325374
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The targeting vector was designed to knock in S356A/T357A/T363A/S369A quadruple mutants in exon 4 to express phosphorylation deficient receptor. The neomycin resistance cassette is self-excising. (J:325374)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Oprk1 Mutation: 28 strains or lines available

References

• Original: J:325374 Huang P, et al., Agonist-promoted kappa opioid receptor (KOR) phosphorylation has behavioral endpoint-dependent and sex-specific effects. Neuropharmacology. 2022 Jan 1;202:108860
• All: 1 reference(s)