Bcl6^tm2.1Cdon
Targeted Allele Detail

Summary

• Symbol: Bcl6^tm2.1Cdon
• Name: B cell leukemia/lymphoma 6; targeted mutation 2.1, Chen Dong
• MGI ID: MGI:6505476
• Synonyms: Bcl6^fl
• Gene: Bcl6 Location: Chr16:23783802-23807602 bp, - strand Genetic Position: Chr16, 15.26 cM
• Alliance: Bcl6^tm2.1Cdon page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:260660
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted 5' to exon 8 and a second loxP site and an frt-flanked neomycin selection cassettte were inserted 3' to exon 9. The neomycin selection cassette was removed via FLP-mediated recombination in the germline. (J:260660)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bcl6 Mutation: 60 strains or lines available

References

• Original: J:260660 Liu X, et al., Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation. Cell Rep. 2016 Feb 23;14(7):1735-1747
• All: 5 reference(s)