Ephx2^tm1.1Smoc
Targeted Allele Detail

Summary

• Symbol: Ephx2^tm1.1Smoc
• Name: epoxide hydrolase 2, cytoplasmic; targeted mutation 1.1, Shanghai Model Organisms Center
• MGI ID: MGI:6505328
• Synonyms: Ephx2^loxp
• Gene: Ephx2 Location: Chr14:66321823-66361949 bp, - strand Genetic Position: Chr14, 34.36 cM, cytoband D
• Alliance: Ephx2^tm1.1Smoc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:276521
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a second loxP site and an FRT site flanked neomycin resistance gene cassette into intron 2. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:276521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ephx2 Mutation: 41 strains or lines available

References

• Original: J:276521 Xiong W, et al., Astrocytic Epoxyeicosatrienoic Acid Signaling in the Medial Prefrontal Cortex Modulates Depressive-like Behaviors. J Neurosci. 2019 Jun 5;39(23):4606-4623
• All: 4 reference(s)