Atf3^tm2.1Kitab
Targeted Allele Detail

Summary

• Symbol: Atf3^tm2.1Kitab
• Name: activating transcription factor 3; targeted mutation 2.1, Shigetaka Kitajima
• MGI ID: MGI:6502676
• Synonyms: Atf3^f
• Gene: Atf3 Location: Chr1:190902493-190915530 bp, - strand Genetic Position: Chr1, 96.28 cM, cytoband H6
• Alliance: Atf3^tm2.1Kitab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:228274
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a loxP site flanked neomycin resistance gene cassette into intron 2 2. The neo cassette was removed through subsequent cre-mediated recombination, leaving a conditional-ready allele with exon 2 floxed. (J:228274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf3 Mutation: 23 strains or lines available

References

• Original: J:228274 Taketani K, et al., Key role of ATF3 in p53-dependent DR5 induction upon DNA damage of human colon cancer cells. Oncogene. 2012 Apr 26;31(17):2210-21
• All: 4 reference(s)