Prdm16^tm1.1Ydu
Targeted Allele Detail

Summary

• Symbol: Prdm16^tm1.1Ydu
• Name: PR domain containing 16; targeted mutation 1.1, Yang Du
• MGI ID: MGI:6502077
• Synonyms: Prdm16^cko
• Gene: Prdm16 Location: Chr4:154400582-154721330 bp, - strand Genetic Position: Chr4, 83.96 cM, cytoband E2
• Alliance: Prdm16^tm1.1Ydu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:299741
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 6. An FRT-flanked PGK blast with a 3' loxP site was inserted downstream of exon 12. Flp-mediated recombination removed the selection cassette and left exons 6 through 12 floxed. (J:299741)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prdm16 Mutation: 73 strains or lines available

References

• Original: J:299741 Gudmundsson KO, et al., Prdm16 is a critical regulator of adult long-term hematopoietic stem cell quiescence. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31945-31953
• All: 1 reference(s)