Aldh3a2^{tm1c(EUCOMM)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Aldh3a2^{tm1c(EUCOMM)Wtsi}
• Name: aldehyde dehydrogenase family 3, subfamily A2; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:6502075
• Synonyms: Aldh3a2 loxp
• Gene: Aldh3a2 Location: Chr11:61114240-61158267 bp, - strand Genetic Position: Chr11, 37.96 cM
• Alliance: Aldh3a2^{tm1c(EUCOMM)Wtsi} page
• IMPC: Aldh3a2 gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:300209
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 61152681 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 61153817. The critical exon(s) is/are thus flanked by loxP sites. v Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:300209)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aldh3a2 Mutation: 32 strains or lines available

References

• Original: J:300209 Yusuf RZ, et al., Aldehyde dehydrogenase 3a2 protects AML cells from oxidative death and the synthetic lethality of ferroptosis inducers. Blood. 2020 Sep 10;136(11):1303-1316
• All: 1 reference(s)