Htt^tm4.1Ics
Targeted Allele Detail

Summary

• Symbol: Htt^tm4.1Ics
• Name: huntingtin; targeted mutation 4.1, Mouse Clinical Institute
• MGI ID: MGI:6501794
• Synonyms: Hdh^{S1181D/S1201D}
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm4.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:198425
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Mutations were engineered in exon 27 to change serine codons (TCA) 1160 and 1180 to aspartic acid codons (CTA) (p.S1160D, p.S1180D). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 27 was removed through subsequent cre-mediated recombination. The substitution of the two serines with aspartic acids acts as a phosphomimic (i.e. mimics the constitutive phosphorylation of the two residues). (J:198425)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 176 strains or lines available

References

• Original: J:198425 Ben M'Barek K, et al., Huntingtin mediates anxiety/depression-related behaviors and hippocampal neurogenesis. J Neurosci. 2013 May 15;33(20):8608-20
• All: 2 reference(s)