Gt(ROSA)26Sor^{tm5(RET*,tdTomato)Cos}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm5(RET*,tdTomato)Cos}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 5, Franklin Costantini
• MGI ID: MGI:6501783
• Synonyms: Rosa26-RetPTC2-H2BTom
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm5(RET*,tdTomato)Cos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:305439
• Parent Cell Line: KV1 (ES Cell)
• Strain of Origin: (C57BL/6J x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm5(RET*,tdTomato)Cos} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

  lacks the RET extracellular domain

• Mutation details: The targeting vector is designed with, from 5' to 3', a floxed-STOP cassette that contains a neomycin resistance gene, a mutant form of the human ret proto-oncogene (RET) cDNA, a viral T2A sequence, and a human histone H2B fused to a constitutively active red enhanced green fluorescence protein (tdTomato). The altered Ret sequence lacks the RET extracellular domain, which signals independently of GDNF, and is found in some patients with papillary thyroid carcinomas. (J:305439)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1095 strains or lines available

References

• Original: J:305439 Packard A, et al., Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formation. Development. 2021 May 1;148(9):dev199386
• All: 1 reference(s)