Il1b^em2Lutzy
Endonuclease-mediated Allele Detail

Summary

• Symbol: Il1b^em2Lutzy
• Name: interleukin 1 beta; endonuclease-mediated mutation 1, Cathy Lutz
• MGI ID: MGI:6501517
• Synonyms: Il1b^del286
• Gene: Il1b Location: Chr2:129206490-129213059 bp, - strand Genetic Position: Chr2, 62.97 cM, cytoband F
• Alliance: Il1b^em2Lutzy page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 genome editing is used to generate a 286 nucleotide deletion that includes all of exon 3 (CCAGAGCACCCA //del286//AACGGGAAGGGA). Loss of exon 3 is predicted to generate a null allele. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Il1b Mutation: 24 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)