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Atriptm1.1Pof
Targeted Allele Detail
Nomenclature
Symbol: Atriptm1.1Pof
Name: ATR interacting protein; targeted mutation 1.1, Pierre-Olivier Frappart
MGI ID: MGI:6501143
Synonyms: AtripFlox
Gene: Atrip  Location: Chr9:108888815-108903192 bp, - strand  Genetic Position: Chr9, 59.63 cM, cytoband F2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:299031
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsA loxP site was inserted upstream of exon 1 and an FRT site flanked neomycin resistance gene cassette and a second loxP site into intron 3. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 1-3 floxed. (J:299031)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 24 assay results
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atrip Mutation:  23 strains or lines available
References
Original:  J:299031 Matos-Rodrigues GE, et al., ATRIP protects progenitor cells against DNA damage in vivo. Cell Death Dis. 2020 Oct 28;11(10):923
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory