Gabra2^tm1Stmo
Targeted Allele Detail

Summary

• Symbol: Gabra2^tm1Stmo
• Name: gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 1, Stephen J Moss
• MGI ID: MGI:6501040
• Synonyms: Myc-pHluorin GABAAR alpha2
• Gene: Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
• Alliance: Gabra2^tm1Stmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:235037
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Epitope tag, Reporter)
• Mutation: Insertion
• Mutation details: A targeting vector was constructed to insert a pHluorin (pH-sensitive EGFP) reporter cDNA and sequence coding for a Myc tag into exon 3 between codons for amino acids 4 and 5 of the mature protein. (J:235037)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra2 Mutation: 37 strains or lines available

References

• Original: J:235037 Nakamura Y, et al., Proteomic Characterization of Inhibitory Synapses Using a Novel pHluorin-tagged gamma-Aminobutyric Acid Receptor, Type A (GABAA), alpha2 Subunit Knock-in Mouse. J Biol Chem. 2016 Jun 3;291(23):12394-407
• All: 3 reference(s)