Mef2a^tm1.1Meg
Targeted Allele Detail

Summary

• Symbol: Mef2a^tm1.1Meg
• Name: myocyte enhancer factor 2A; targeted mutation 1.1, Michael E Greenberg
• MGI ID: MGI:6491891
• Synonyms: Mef2a^fl
• Gene: Mef2a Location: Chr7:66880911-67022606 bp, - strand Genetic Position: Chr7, 36.72 cM
• Alliance: Mef2a^tm1.1Meg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:288340
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a floxed neomycin selection cassette was inserted downstream of exon 2 via homologous recombination. A third loxP site was inserted at the 3' end of the coding sequence. Cre mediated recombination removed the neomycin selection cassette. (J:288340)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mef2a Mutation: 34 strains or lines available

References

• Original: J:288340 Andzelm MM, et al., A Late Phase of Long-Term Synaptic Depression in Cerebellar Purkinje Cells Requires Activation of MEF2. Cell Rep. 2019 Jan 29;26(5):1089-1097.e3
• All: 3 reference(s)