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Ano5em1Huyi
Endonuclease-mediated Allele Detail
Summary
Symbol: Ano5em1Huyi
Name: anoctamin 5; endonuclease-mediated mutation 1, Ying Hu
MGI ID: MGI:6489964
Synonyms: Ano5-
Gene: Ano5  Location: Chr7:51160777-51248457 bp, + strand  Genetic Position: Chr7, 32.76 cM
Alliance: Ano5em1Huyi page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCRISPR/Cas9 technology created an 833 bp deletion encompassing exons 11 and 12 and generated a truncated transcript of 660 bp. (J:294237)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 11 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ano5 Mutation:  67 strains or lines available
References
Original:  J:294237 Wang X, et al., Genetic Disruption of Anoctamin 5 in Mice Replicates Human Gnathodiaphyseal Dysplasia (GDD). Calcif Tissue Int. 2019 Jun;104(6):679-689
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory