Cyp19a1^tm1.2Hzh
Targeted Allele Detail

Summary

• Symbol: Cyp19a1^tm1.2Hzh
• Name: cytochrome P450, family 19, subfamily a, polypeptide 1; targeted mutation 1.2, Hong Zhao
• MGI ID: MGI:6489610
• Synonyms: Arom^del, Arom^ko
• Gene: Cyp19a1 Location: Chr9:54073221-54175394 bp, - strand Genetic Position: Chr9, 29.49 cM
• Alliance: Cyp19a1^tm1.2Hzh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298580
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the promotor and an FRT-flanked neomycin resistance cassette and a second loxP site were inserted in intron 2. The loxP-flanked region encompasses 4.9-kb of the promoter region, 0.6-kb of the gonad-specific first exon (PII), exon 2, and part of intron 2. Flp-mediated recombination removed the neomycin selection cassette and cre-mediated recombination deleted the floxed region (promotor, exon 1 and exon 2). (J:298580)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cyp19a1 Mutation: 38 strains or lines available

References

• Original: J:298580 Brooks DC, et al., Brain Aromatase and the Regulation of Sexual Activity in Male Mice. Endocrinology. 2020 Oct 1;161(10)
• All: 1 reference(s)