Carns1^tm1.1Meck
Targeted Allele Detail

Summary

• Symbol: Carns1^tm1.1Meck
• Name: carnosine synthase 1; targeted mutation 1.1, Matthias Eckhardt
• MGI ID: MGI:6489596
• Synonyms: Carns1^f
• Gene: Carns1 Location: Chr19:4214323-4225478 bp, - strand Genetic Position: Chr19, 3.86 cM
• Alliance: Carns1^tm1.1Meck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298850
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was introduced into intron 2 and a loxP and FRT site flanked neomycin resistance gene cassette plus duplicate sequence of the 3' end of exon 10 were inserted downstream of exon 10. The neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exons 3-10 floxed. (J:298850)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Carns1 Mutation: 34 strains or lines available

References

• Original: J:298850 Wang-Eckhardt L, et al., Carnosine synthase deficiency is compatible with normal skeletal muscle and olfactory function but causes reduced olfactory sensitivity in aging mice. J Biol Chem. 2020 Dec 11;295(50):17100-17113
• All: 1 reference(s)