Hbp1^tm1.1Cmsu
Targeted Allele Detail

Summary

• Symbol: Hbp1^tm1.1Cmsu
• Name: high mobility group box transcription factor 1; targeted mutation 1.1, Cam-Su Genomic Resource Center
• MGI ID: MGI:6489578
• Gene: Hbp1 Location: Chr12:31976449-32000529 bp, - strand Genetic Position: Chr12, 13.73 cM
• Alliance: Hbp1^tm1.1Cmsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:259864
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and loxP site were inserted downstream of exon 3 via homologous recombination. Recombinase mediated recombination removed exons 2 and 3 and the neo cassette. (J:259864)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hbp1 Mutation: 41 strains or lines available

References

• Original: J:259864 Dong Z, et al., Focused screening of mitochondrial metabolism reveals a crucial role for a tumor suppressor Hbp1 in ovarian reserve. Cell Death Differ. 2016 Oct;23(10):1602-14
• All: 1 reference(s)