Epx^{tm2.1(HBEGF)Jlee}
Targeted Allele Detail

Summary

• Symbol: Epx^{tm2.1(HBEGF)Jlee}
• Name: eosinophil peroxidase; targeted mutation 2.1, James Lee
• MGI ID: MGI:6489574
• Synonyms: EPX^{tm1.1(DTR)JLee}, iPHIL-epx
• Gene: Epx Location: Chr11:87754826-87766362 bp, - strand Genetic Position: Chr11, 52.25 cM
• Alliance: Epx^{tm2.1(HBEGF)Jlee} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:266723
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Epx^{tm2.1(HBEGF)Jlee} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HBEGF (1839)

  Hbegf

  (MGI:96070)

• Mutation details: The knock-in allele contains a human Diptheria Toxin receptor (HBEGF) driven by the endogenous promoter and followed by an IRES sequence then the endogenous coding sequence. Cre-recombination removed the floxed neomycin selection cassette. (J:266723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Epx Mutation: 34 strains or lines available

References

• Original: J:266723 Jacobsen EA, et al., Eosinophil activities modulate the immune/inflammatory character of allergic respiratory responses in mice. Allergy. 2014 Mar;69(3):315-27
• All: 3 reference(s)