Bccip^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Bccip^{tm1c(EUCOMM)Hmgu}
• Name: BRCA2 and CDKN1A interacting protein; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6489522
• Synonyms: Bccip^f
• Gene: Bccip Location: Chr7:133311062-133322874 bp, + strand Genetic Position: Chr7, 77.3 cM, cytoband F4
• Alliance: Bccip^{tm1c(EUCOMM)Hmgu} page
• IMPC: Bccip gene page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:297226
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: EUCOMM

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_gt0 cassette was inserted at position 133318877 of Chromosome 7 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 133319805. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:297226)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bccip Mutation: 22 strains or lines available

References

• Original: J:297226 Lu H, et al., Spontaneous Development of Hepatocellular Carcinoma and B-Cell Lymphoma in Mosaic and Heterozygous Brca2 and Cdkn1a Interacting Protein Knockout Mice. Am J Pathol. 2020 Jun;190(6):1175-1187
• All: 3 reference(s)