Dagla^tm1.1Patel
Targeted Allele Detail

Summary

• Symbol: Dagla^tm1.1Patel
• Name: diacylglycerol lipase, alpha; targeted mutation 1.1, Sachin Patel
• MGI ID: MGI:6489509
• Synonyms: Dagla^fl, DAGL^f
• Gene: Dagla Location: Chr19:10222629-10282241 bp, - strand Genetic Position: Chr19, 6.55 cM
• Alliance: Dagla^tm1.1Patel page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:244431
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A targeting vector comprised of an frt-flanked neomycin selection cassette and loxP sites flanking exon 9 was inserted into position 10261203 of Chromosome 19, upstream of exon 8. The neomycin selection cassette was removed via FLP-mediated recombination in the germline, leaving the loxP sites flanking exon 9. (J:244431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dagla Mutation: 62 strains or lines available

References

• Original: J:244431 Bluett RJ, et al., Endocannabinoid signalling modulates susceptibility to traumatic stress exposure. Nat Commun. 2017 Mar 28;8:14782
• All: 7 reference(s)