Adam28^tm1.2Dica
Targeted Allele Detail

Summary

• Symbol: Adam28^tm1.2Dica
• Name: a disintegrin and metallopeptidase domain 28; targeted mutation 1.2, Didier Cataldo
• MGI ID: MGI:6488446
• Synonyms: ADAM28 KO
• Gene: Adam28 Location: Chr14:68843476-68893291 bp, - strand Genetic Position: Chr14, 35.69 cM, cytoband D1
• Alliance: Adam28^tm1.2Dica page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:298188
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted into intron 1 and an FRT site flankled neomycin resistance gene cassette and a second loxP site into intron 2. The neo cassette was removed through subsequent flp-mediated recombination and floxed exon 2 was deleted through subsequent cre-mediated recombination. (J:298188)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam28 Mutation: 56 strains or lines available

References

• Original: J:298188 Gerard C, et al., Microenvironment-derived ADAM28 prevents cancer dissemination. Oncotarget. 2018 Dec 14;9(98):37185-37199
• All: 1 reference(s)