Jchain^{em1(icre/ERT2)Deep}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Jchain^{em1(icre/ERT2)Deep}
• Name: immunoglobulin joining chain; endonuclease-mediated mutation 1, Deepta Bhattacharya
• MGI ID: MGI:6478203
• Synonyms: JchainCreERT2
• Gene: Jchain Location: Chr5:88667663-88675667 bp, - strand Genetic Position: Chr5, 43.7 cM
• Alliance: Jchain^{em1(icre/ERT2)Deep} page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Jchain^{em1(icre/ERT2)Deep} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Jchain (MGI:96493)

• Mutation details: Using CRISPR/Cas9 technology, the allele was generated to insert an IRES sequence and a CreER(T2) fusion gene into the 3' UTR of the immunoglobulin joining chain locus (Jchain) on chromosome 5. (J:297378)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Jchain (mouse) Summary of all recombinase alleles driven by Jchain. Alliance mouse Jchain gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jchain Mutation: 22 strains or lines available

References

• Original: J:297378 Wong R, et al., Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. Immunity. 2020 Nov 17;53(5):1078-1094.e7
• All: 1 reference(s)