Aicda^{tm1c(EUCOMM)Hmgu}
Targeted Allele Detail

Summary

• Symbol: Aicda^{tm1c(EUCOMM)Hmgu}
• Name: activation-induced cytidine deaminase; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
• MGI ID: MGI:6478196
• Synonyms: Aicda^f
• Gene: Aicda Location: Chr6:122530768-122541139 bp, + strand Genetic Position: Chr6, 57.65 cM, cytoband F2
• Alliance: Aicda^{tm1c(EUCOMM)Hmgu} page

Mutation origin

• Mutant Cell Line: HEPD0615_4_C05
• Germline Transmission: Earliest citation of germline transmission: J:297378
• Parent Cell Line: JM8A3.N1 (ES Cell)
• Strain of Origin: C57BL/6N-A^tm1Brd

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion Vector: L1L2_Bact_P
• Mutation details: FLPe-mediated excision of the parental Aicda^{tm1a(EUCOMM)Hmgu} allele resulted in the removal of the lacZ reporter sequence and promoter-driven neomycin selection cassette leaving exon 3 flanked by loxP sites. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml. (J:297378)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Aicda Mutation: 57 strains or lines available

References

• Original: J:297378 Wong R, et al., Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses. Immunity. 2020 Nov 17;53(5):1078-1094.e7
• All: 2 reference(s)