Fgfr2^tm8.1Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm8.1Sor
• Name: fibroblast growth factor receptor 2; targeted mutation 4.1, Philippe Soriano
• MGI ID: MGI:6477581
• Synonyms: Fgfr2^FCPG
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm8.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303230
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Nucleotide substitutions
• Mutation details: The targeting vector from Fgfr2^tm3.1Sor containing the L443A and R445A substitutions in exon 10 and a FRT-flanked neomycin-resistance gene followed by a loxP site located upstream of exon 10 is used to retarget ES cells derived from Fgfr2^tm7.1Sor carrying the Y485F, Y788F and Y798F mutations. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:303230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 88 strains or lines available

References

• Original: J:303230 Ray AT, et al., FGF signaling regulates development by processes beyond canonical pathways. Genes Dev. 2020 Dec 1;34(23-24):1735-1752
• All: 3 reference(s)