Fgfr2^tm3.1Sor
Targeted Allele Detail

Summary

• Symbol: Fgfr2^tm3.1Sor
• Name: fibroblast growth factor receptor 2; targeted mutation 3.1, Philippe Soriano
• MGI ID: MGI:6477572
• Synonyms: Fgfr2^F
• Gene: Fgfr2 Location: Chr7:129764181-129868538 bp, - strand Genetic Position: Chr7, 73.19 cM
• Alliance: Fgfr2^tm3.1Sor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:303230
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Not Specified)
• Mutation: Nucleotide substitutions
• Mutation details: Site-directed mutagenesis was used to insert nucleotide substitutions in exon 10 of the locus, altering leucine to alanine at codon 443 (L443A - CTG to GCC) and arginine to alanine at codon 445 (R445A - AGA to GCA) and introducing an Xma1 site. The substitutions were initially described as L424A and R426A respectively. In addition, a FRT-flanked neomycin-resistance gene followed by a loxP site was located upstream of exon 10. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:303230)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Fgfr2 Mutation: 88 strains or lines available

References

• Original: J:303230 Ray AT, et al., FGF signaling regulates development by processes beyond canonical pathways. Genes Dev. 2020 Dec 1;34(23-24):1735-1752
• All: 1 reference(s)