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Fgfr2tm4.1Sor
Targeted Allele Detail
Summary
Symbol: Fgfr2tm4.1Sor
Name: fibroblast growth factor receptor 2; targeted mutation 4.1, Philippe Soriano
MGI ID: MGI:6477570
Synonyms: Fgfr2C
Gene: Fgfr2  Location: Chr7:129764181-129868538 bp, - strand  Genetic Position: Chr7, 73.19 cM
Alliance: Fgfr2tm4.1Sor page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:303230
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Not Applicable)
Mutation:    Nucleotide substitutions
 
Mutation detailsSite-directed mutagenesis was used to insert nucleotide substitutions in exon 11 of the locus, altering tyrosine to phenylalanine at codon 485 (Y485F-TAT to TTT) and a silent mutation, leucine to leucine at codon 487 (L487L -TTG to CTC) and introducing a Sac1 site. The substitutions were initially described as Y466F and L468L, respectively. In addition, a loxP and FRT-flanked neomycin-resistance gene was located downstream of exon 11. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:303230)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  88 strains or lines available
References
Original:  J:303230 Ray AT, et al., FGF signaling regulates development by processes beyond canonical pathways. Genes Dev. 2020 Dec 1;34(23-24):1735-1752
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory