Ncs1^tm1.2Cipmm
Targeted Allele Detail

Summary

• Symbol: Ncs1^tm1.2Cipmm
• Name: neuronal calcium sensor 1; targeted mutation 1.2, Center for Integrative Physiology and Molecular Medicine
• MGI ID: MGI:6477319
• Gene: Ncs1 Location: Chr2:31135835-31186001 bp, + strand Genetic Position: Chr2, 21.81 cM, cytoband B
• Alliance: Ncs1^tm1.2Cipmm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:230829
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An EGFP reporter gene and floxed neomycin resistance cassette was inserted downstream of exon 7. Cre-mediated recombination removed exons 4 through 7 and the EGFP and selection cassette. (J:230829)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ncs1 Mutation: 15 strains or lines available

References

• Original: J:230829 Ng E, et al., Neuronal calcium sensor-1 deletion in the mouse decreases motivation and dopamine release in the nucleus accumbens. Behav Brain Res. 2016 Mar 15;301:213-25
• All: 7 reference(s)